My group is interested in how the epigenetic landscape is established during oogenesis and the impact gamete-derived epigenetic marks have on gene regulation after fertilisation, such as at imprinted genes.
We investigate how transcription, acting through effects on chromatin state, directs the DNA methylation landscape, the chromatin modifier factors involved, and how the DNA methylation complex is recruited.
With this knowledge, we are interested to identify the extent to which normal epigenetic patterns in the oocyte and embryo could be perturbed by altered diet and physiology. To approach these questions, we develop and deploy genome-wide profiling methods for low cell numbers, including in single cells, and use genetic models in the mouse.
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